• Stimulates Protein Synthesis
• Reduces Inflammation
• Reduces Protein Breakdown
• Reduces Body Fat
• Increases Lean Muscle Mass

Building Muscle . . .

The quality and quantity of muscle that each of us possess is essentially controlled by protein turnover; a remodeling process that involves the continuous synthesis (anabolism) and breakdown (catabolism) of muscle protein. A gain in muscle mass can only occur via a reduction in the rate at which protein is broken down or an increase in the rate of protein synthesis. However, intense exercise causes a dramatic increase in protein turnover; both synthesis and breakdown accelerate at equal rates. The result is a negative protein balance and zero muscle gains from training.

Myo-D’s unique formulation is shown in research to reduce muscle breakdown and stimulate an increase in protein synthesis. Myo-D promotes muscle gains during intense training by enhancing not one, but the two key processes that are essential to gaining muscle mass.

63-0447 AST Myo-D 120 softgels Nutrition Facts Serving Size: 4 Softgels Servings Per Container: 30 Amount Per Serving % Daily Value* Total Calories 26      Total Fat 2  g 3%       Saturated Fat 0  g <1%       Polyunsaturated Fat 1.5  g      Monounsaturated Fat 0  g      Trans Fat 0  g   Cholesterol 0  mg 0%    Total Carbohydrates 1  g <1%    Protein 1.2  g 2%    Average Amino Acid Profile Per Serving   L-Leucine 1000  mg   L-Methionine 500  mg   L-Arginine 500  mg   Fish Oil Concentrate 2000  mg   Omega-3 Fatty Acids 1250  mg   Eicosapentaenoic Acid 1050  mg   Docosahexaenoic Acid 200  mg   Unsaturated Fat 1.8  g 16%    *Percent Daily Values are based on a 2,000 calorie diet. Ingredients: High ratio 5:1 EPA/DHA fish oil, ethyl ester concentrate, gelatin, leucine, glycerin, arginine, methionine powder, safflower oil, purified water, yellow beeswax, carmine dispersion, lecithin, titanium dioxide. Recommended Use: For best results: Take 2 softgels twice daily with meals. Warning: Contains fish and soybeans. Manufactured in a facility that processes milk, eggs, crustacean shellfish, tree nuts, and wheat. Before beginning any program of weight loss, consult your health care practitioner. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. If you notice any errors in the information above, please let us know. If you have further questions about this product, please contact AST at 1-800-627-2788

Reduce muscle breakdown!

Myo-D contains a unique 5:1 ratio of EPA:DHA which means a much more potent dose of bioactive EPA than any other product on the market. EPA (eicosapentaenoic acid) is the naturally occurring compound shown in research to block excessive muscle breakdown by reducing the activity of the major biochemical pathway that results in the destruction of muscle protein and loss of muscle mass. In clinical studies, EPA is shown to work at the molecular level and block muscle protein catabolism by reducing the activity of the ATP-ubiquitin-proteasome proteolytic pathway, the major pathway of protein catabolism in muscle.

Research shows that this pathway is highly active in illnesses that promote muscle wasting, but also active during times of calorie restriction. The capacity of EPA to block excessive muscle protein breakdown is powerful; it’s anti-catabolic effects are shown to be even more potent than IGF-1. If you’re dieting to shed body fat, Myo-D could be you’re best ally. Regular use will help you keep your hard earned muscle during dieting and contest preparation.

Stimulate muscle protein synthesis!

A high stimulation of muscle protein synthesis is essential to gaining muscle mass, but it also underlines rapid recovery. Myo-D also contains a precision blend of the most potent amino acids shown in research to activate protein synthesis within muscle. Therefore, every serving of Myo-D helps to enhance recovery and gains in muscle mass gains via two vital processes.

Firstly, Myo-D’s ultra-high concentration of bioactive EPA blocks excessive protein breakdown. Secondly, Myo-D provides a high dose of the amino acids that directly activate muscle protein synthesis.

In research, the formulation within Myo-D is shown to promote a greater anabolic effect than regular EPA alone or EPA combined with protein.10 Myo-D is scientifically formulated to reduce muscle breakdown and stimulate an increase in protein synthesis. Therefore, Myo-D could be the most powerful, non-prescription bodybuilding supplement available.

Reduce inflammation - speed recovery!

Inflammation is an essential part of immune activation that clears debris and destroys pathogens. However, excessive inflammation produced by intense exercise can result in poor recovery, chronic joint pain and muscle loss. By reducing excess inflammation within muscle and connective tissue will provide the athlete with a big head start in terms of recovery from exercise.

EPA is essential to the manufacture of Series-3 Prostaglandins (short lived muscle growth factors), and Series-5 Leukotrienes (highly active immune cells) that work to reduce muscle inflammation. Therefore, Myo-D’s 5:1 ratio of EPA provides an ultra-high dose that helps reduce tissue inflammation and speed recovery during intense exercise.

Improve insulin metabolism, enhance fat loss!

The cornerstone of building a lean, healthy, physique is efficient insulin metabolism. Insulin is the hormone essential to nutrient transport into cells. Therefore, a dietary compound that can improve insulin metabolism offers a huge advantage for anyone attempting to shed fat or build a lean physique.

The high dose of EPA in Myo-D is shown to promote an insulin-sensitizing effect in tissue, even in healthy people that do not have diabetes. That means more calories are directed towards lean tissue for recovery and growth while less calories are stores as body fat.

EPA is also known to enhance fat metabolism during exercise. Regular supplementation with EPA appears to increase fat utilization during exercise. Therefore, Myo-D’s 5:1 ratio of EPA provides an ultra-high dose that promotes efficient insulin metabolism and greater fat utilization during exercise.

Myo-D promotes a high rate of muscle anabolism by minimizing protein breakdown and stimulating protein synthesis. Regular use of Myo-D will also help improve insulin metabolism and promote better fat loss during exercise training. Clearly, no other dietary supplement is shown in research to provide bodybuilders with so many important advantages that help build a lean, muscular physique.

References:

Barber MD; Fearon KC; Tisdale MJ; McMillan DC; Ross JA. Effect of a fish oil-enriched nutritional supplement on metabolic mediators in patients with pancreatic cancer cachexia. Nutr Cancer 40; 118-24, 2001.

Whitehouse AS, Tisdale MJ. Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation. Biochem Biophys Res Commun 285; 598-602, 2001.

Barber MD. Cancer cachexia and its treatment with fish-oil-enriched nutritional supplementation. Nutrition 2001;17:751-755.

Whitehouse AS, Smith HJ, Drake JL, Tisdale MJ. Mechanism of attenuation of skeletal muscle protein catabolism in cancer cachexia by eicosapentaenoic acid. Cancer Res 2001;61:3604-3609.

Stephens CB. Fish Oil and Inflammatory Disease. Nutrition Reviews 62 (12);486-489, 2004.

Bradshaw RA, Brickley WN, Walker KW. N-terminal processing: the methionine aminopeptidase and N-alpha-acetyl transferase families. Trends Biochem Sci 23; 263,1998.

Tesseraud S, Bigot K, Toovis M Amino acid availability regulates S6K1 and protein synthesis in avian insulin-insensitive QMT myoblasts. FEBS Lett 540; 176-181, 2003.

Vissers YLJ, von Meyenfeldt MF, Deutz MEP. Arginine production in intestine, liver, muscle and kidney is reduced in tumour-bearing mice undergoing surgery. Eur J Gastroenterol Hepatol 14;A59-A64., 2002.

Smith HJ, NA Greenberg and MJ Tisdale. Effect of eicosapentaenoic acid, protein and amino acids on protein synthesis and degradation in skeletal muscle of cachectic mice. British Journal of Cancer 91; 408-412, 2004.

Delarue J, Chang-Hong L, Richard C, Charlotte C, Brigitte S. Interaction of fish oil and a glucocorticoid on metabolic responses to an oral glucose load in healthy human subjects. Br J Nutr. 2006 Feb;95(2):267-72.

Hufman DM, Michaelson JL, Thomas TR. Chronic supplementation with fish oil increases fat oxidation during exercise in young men. JEPonline. 7(1):48-56, 2004.

Kimura Y, Sumiyoshi M. Antitumor and antimetastatic actions of eicosapentaenoic acid ethylester and its by-products formed during accelerated stability testing. Cancer Sci. 96(7):441-50, 2005.

A Nordoy, L Barstad, WE Connor, and L Hatcher. Absorption of the n-3 eicosapentaenoic and docosahexaenoic acids as ethyl esters and triglycerides by humans. Am. J. Clinical Nutrition, 53: 1185 – 1190, 1991.

Tremoli E, P Maderna, F Marangoni, S Colli, S Eligini, I Catalano, MT Angeli, F Pazzucconi, G Gianfranceschi, and G Davi. Prolonged inhibition of platelet aggregation after n-3 fatty acid ethyl ester ingestion by healthy volunteers. Am. J. Clinical Nutrition, 61: 607 – 613, 1995.

Grimsgaard, KH Bonaa, JB Hansen, and A Nordoy. Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. Am. J. Clinical Nutrition, 66: 649 – 659, 1997.