D.O.M.S. Recovery Enzymes

SORENZYME™ is the collaborative effort of Labrada’s Research & Development team and Dr. Mark J. Tallon, a Nutritional Biochemist who is also one of the industry’s leading minds in nutrient metabolism. Combining two proven systems in immune and inflammatory control resulted in a supplement that was safe, effective, all natural, and the first of its kind in the sports nutrition market to control D.O.M.S. (Delayed Onset Muscle Soreness) and deliver body-transforming results.

The ingredients in SORENZYME™ have been shown to reduce D.O.M.S., post exercise inflammation, and improve immune function. Additionally, there is evidence that the immune enhancing/anti-inflammatory action can keep increasing for up to 6 months with continued use. (Miller et al. 1999). This means the longer you take SORENZYME™, the better the effects. The data suggests a cumulative effect of the protease enzymes by either the body’s “up-regulating” of its own protection system or by the storage of the supplemented enzymes in muscle tissue until there is a greater need for muscle repair, as with muscle damage and training.

The Ingredients in SORENZYME™ give you:

• Faster rate of recovery between workouts
• Lower loss of force production after workouts
• Less muscle soreness from activity
• Lower risk of injury from activity
• Increased immune function
• Attenuates Delayed-Onset Muscle Soreness (D.O.M.S.), the postworkout soreness that prevents you from making faster muscle gains.
• Can reduce post-workout inflammation to speed recovery time by up to 63%
• Unique anti-catabolic formulation protects against post-workout cortisol elevation. Cortisol is a stress hormone that eats away at muscle and promotes body fat.

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Find similar products fitting all of the checked categories. Digestion/Enzymes    Inflammation      Immune System Support    Post Workout Muscle Recovery

Sorenzyme (Labrada) - Average rating (1 review)  - Write a review Show Reviews Reviews (0) (1) (0) (0) (0)   May 14, 2010 Reviewer: Jeff in Iowa I have less soreness and inflammation after training but the most important to me is I have not been sick since I started taking Sorenzyme 6 months ago. I love not having any nagging colds passed around anymore!! Was this review helpful to you? Yes  No

86-0643 Labrada Sorenzyme 120 capsules Nutrition Facts Serving Size: 4 Capsules Servings Per Container: 30 Amount Per Serving % Daily Value* Protease (500000 HUT/g) 867  mg   Trypsin (1:150 min 150 USP/mg) 20  mg   Bromelain (3300 GDU/g) 45  mg   Lysozyme chloride (22800 U/mg) 27  mg   Chymotrypsin (1000 U/mg) 5  mg   Papain (50000 USP/mg) 133  mg   Amylase (100000 SKB/mg) 27  mg   Lipase (50000 FIP/g) 27  mg   Beta-sitosterol (60/100 min) 20  mg   Beta-sitosterol glucoside 1200  mcg   Piper nigrum (95% piperine) 5  mg   *Percent Daily Values are based on a 2,000 calorie diet.   Other Ingredients: Rice flour, silica, magnesium stearate Recommended Use: Take four capsules once daily at least 45 minutes before a meal or as recommended by your health care professional. Elite level athletes, take four capsules twice daily. Warning: The ingredients in Sorenzyme are 100% natural and non-toxic; however, because many of the enzymes in this formula have an anti-coagulating effect, people taking any type of blood-thinning medications, asprin, and/or non-steroidal anti-inflammatory drugs should seek medical advice from their physician before using. All users are advised to consult their physician before starting any dietary supplement and/or exercise program. Pregnant or lactating women should not use this product. Before beginning any program of weight loss, consult your health care practitioner. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. If you notice any errors in the information above, please let us know. If you have further questions about this product, please contact Labrada at 1-800-832-9948 The nutrition facts listed above are supplied as a courtesy to our customers. The nutrition facts were current and accurate to the best of our knowledge at the time they were entered. Manufacturers often change formulas or ingredients without notifying us. We do our best to keep them as up to date as possible, however Netrition.com will not be held responsible for any differences between what is listed on our web site and what is listed on the product that you receive. If you need to be 100% certain of the ingredients currently being shipped, we recommend that you call or email our customer service department to check the shelf of current stock.

Before you can fully appreciate the benefits of SORENZYME™ you must first understand the very problem that SORENZYME™ is designed to combat—the unwanted side effects of intense exercise.

When you exercise to the point where the training load exceeds your physical capacity, you damage muscle tissue. This damage is actually the goal of weight training, i.e. to first cause muscle damage, then to optimize muscle repair through diet and rest—so the muscle can adapt to the stress placed on it by growing stronger. There are initially two parts to muscle damage from exercise, particularly eccentric exercise which leads to a lengthening of the muscle under tension. First, there is immediate mechanical damage; second, there is inflammation.

This second part is associated with changes in the chemical processes within muscle, such as inflammation and immune system suppression. The results of these effects are well known and commonly include, edema, pain, and immobility, with the latter as the reason for athletes being “out of the fight.” These processes tend to peak up to 24-72 hours following exercise. In other words, this means a VERY BIG window of time before your muscles can function optimally again.

Now, imagine if you could reduce this window with supplementation? That’s right! You would benefit from increased recovery, growth, and physical performance.

As we briefly mentioned, inflammation is a major contributor to muscle damage and, more specifically, to the length of time it takes muscles to recover. Your natural response to any form of tissue damage whether through exercise (Muscle) or trauma (Sprain) is an increase in acute inflammation. The entrance of white blood cells into the damaged tissue (i.e. muscle) affects the degree of inflammation in damaged tissue. White blood cells are controlled by a group of specific cells called cytokines. These cytokines can act as either proinflammatory (increases inflammation) or anti-inflammatory (decrease inflammation) depending on which types are activated.

Another regulatory factor in the inflammatory response is your natural ability to recover between exercise bouts. Without adequate recovery, the muscle damage and cumulative depletion of vital nutrients and enzymes lead to over-training, which is a state of decreased adaptation from exercise, lower performance levels, and a heightened incidence of fatigue.

Therefore, the inflammatory response could be looked upon as a marker of injury and of your recovery capacity. Because very little inflammation is needed to bring about an adaptive response in your muscle following exercise, decreasing excessive inflammation could, in theory, enhance your RECOVERY and consequently, GAINS from exercise.

So, what nutritional and supplemental strategies can we best use to ameliorate these unwanted side effects of intense exercise?

Proteolytic Enzymes

What are they?

Protease supplementation is believed to inhibit the production of pro-inflammatory agents while stimulating the production of anti-inflammatory agents (Woolf et al. 1965; Vellini et al. 1986; Taussig and Batkin 1988). The net result is “Less Inflammation.”

How do they work?

Unlike aspirin-type drugs that can cause sever gastrointestinal upset and that can inhibit all types of good and bad prostaglandins (prostaglandin = a fatty acid based compound which plays a role in inflammation) (Donoho and Rylander 1962; Cirelli 1964; Deitrick 1965; Spaeth 1968; Seligman 1969), protease enzymes, such as those included in the SORENZYME™ formula, cause none of these undesirable effects yet still produce the beneficial anti-inflammatory effects (Taussig 1980). The specifics on the protease mechanism of action are complex, but here is a brief overview: The anti-inflammatory action of protease is associated with increased tissue permeability, facilitating resorption of edema (tissue fluid build up) and accelerated recovery of damaged muscle tissue (Cirelli 1964; Smyth et al. 1967).

On a detailed biochemical level, protease supplementation increases proteolytic and fibrinolytic activity of the blood, increases tissue permeability, and inhibits prostaglandin (PGE2) release. These proteolytic enzymes also act on fibrinogen to stimulate the synthesis of anti-inflammatory prostaglandins (Livio et al. 1978; Pirotta et al 1978). Together these powerful antiinflammatory tools give rise to a whole body decrease in tissue inflammation.

Where is the proof?

There is actually an abundance of scientific data! We have found the first studies dating back to 1957 on the influence of protease type enzymes (ingredients in SORENZYME™) and their anti-inflammatory effect (Innerfield 1957), which Calnan and his colleagues subsequently confirmed in 1963.

From the early 60’s onwards, studies directly related to athletes began. In one such study, 225 boxers took a protease supplement 1-1.30 hours before a boxing bout. The results showed significantly less incidence of injury (Blonstein 1967). In a subsequent study on 28 professional soccer players (Chelsea Football club), a significant reduction of time lost on the field from soft-tissue and ligament injury was achieved compared to a placebo and previous seasons. This data provides real world evidence of the effect of enzyme supplements for helping football players, boxers, and those involved in impact and high intensity sports to recover faster. But, what about muscle tissue injury?

In a groundbreaking study by Miller et al (2004), a combination formula of proteolytic enzymes was used with doses at least equal to or less potent than those in SORENZYME™. These researchers investigated the effects of protease supplementation on muscle function and muscle damage following downhill running. The great thing about this study was that they actually measured muscle function following damaging exercise in order to determine how quickly the ability to produce power and strength returned. (As a side note: the damage brought about in this study is greater than the damage you would likely ever face from a gym workout). O.K., so what were the results? Peak strength and speed of leg extension / flexion were assessed both before and after supplementation. Those subjects on the protease supplement had significantly greater recovery of strength and speed measured one day and two days following the muscle damaging exercise. Measures of pain were also significantly lower in the supplementation group. Just as a recap, here are the hard, cold facts for the protease supplemented group versus the placebo group-

“Benefits of Protease Supplementation”:

• 4 TIMES LOWER LOSS IN FORCE PRODUCTION
• HIGHER RATE OF RECOVERY OF FORCE PRODUCTION
• 63% LESS MUSCLE SORENESS
• LOWER INCIDENCE OF INJURY
• INCREASED IMMUNE FUNCTION

As impressive as these results are, SORENZYME™ is actually formulated to yield even greater results than those noted in the aforementioned clinical study. The results of the study show that following muscle damage, such as that caused following resistance-exercise, protease supplementation accelerates your recovery and adaptive responses to allow a faster return to FULL-STRENGTH and more intense workouts. This ultimately leads to greater gains in muscle mass and performance. But, with SORENZYME™ we didn’t stop there!

Greater Post-Workout Recovery

To make SORENZYME™ even more effective, we fortified it with sitosterols (plant sterols.)

What are Sitosterols?

A sterol is a form of lipid found in all higher plants and in low concentrations in human tissues (Pegel 1997). Sterols can also be found and consumed in diets rich in fruits, nuts, seeds, and vegetables.

The structure and function of sterols is very much like that of cholesterol in cell membranes—both acting as a storage and transport agent for fatty acids as well as promoting their conversion to other fatty acids such as Linoleic acid (Leikin and Brenner 1989). These sterols are better known as phytosterols because of their discovery in plants.

How do Sitosterols Work?

Sterols and particularly the beta-sitosterols, as found in SORENZYME,™ have been demonstrated repeatedly to have beneficial effects on health and post exercise recovery. Sitosterol consumption has been shown to increase the activity of some of our body’s most powerful immune cells (T-Cell activity, CD4) and to decrease the levels of inflammatory chemicals (. Beyond this, beta-sitosterols decrease elevated cholesterol levels and also help decrease the catabolic and fat storage hormone cortisol (Bouic et al. 1999). This may mean you not only up-regulate your immune system, but also enhance your ability to maintain muscle mass and lose body fat.

Studies Support Sitosterol’s Benefits

In 1999, a study out of South Africa looked at the effects of beta-sitosterols on post marathon immune suppression and inflammation. Inflammation and muscle damage from running a marathon is usually far higher than that from weight training. Therefore, the positive effects for a bodybuilder/weight training athlete should be even greater than they are for the marathon runners.

Dr. Bouic and colleagues hypothesized clinically proven doses of sitosterols would enhance the immune response to post-exercise inflammation. The results confirmed these hypotheses exactly as supplementation prevented immune suppression and pro-inflammatory responses as defined by cortisol to DHEA ratios (measures of inflammation) and the lower appearance of proinflammatory cytokines among all supplemented athletes.

This shows the concentration of Beta-Sitosterol in SORENZYME™ can really boost your immune system and fight inflammation—which leads to faster recovery and less time out of your training due to illness .

Enhancing Absorption = enhanced results

The absorption of a nutrient must always be considered when using any supplement. For sitosterols, you absorb about 5% of the ingested dose. Protease supplements’ absorption ranges from between 40% for bromelain (Kelly 1997) and greater for mixed protease products (Miller et al. 2004). Although SORENZYME™ already contains dosages clinically shown to enhance performance, recovery, and reduce inflammation, the addition of sitosterols enhances the bio-availability of these active compounds, further accelerating and intensifying their fantastic results.

How is the absorption of SORENZYME™ increased?

Of all nutrients clinically shown to aid absorption, one stands out—piperine. Piperine is a major component of Black Pepper (Piper longum Linn; Piper nigrum Linn) that has been shown to inhibit enzymes that control the transport of different nutrients through the gut (Atal et al. 1981; Velpandian et al. 2001). Piperine has been shown to increase absorption of nutrients up to 60%.

How will you Benefit from SORENZYME™?

The ingredients in SORENZYME™ have been shown to reduce D.O.M.S., post exercise inflammation, and improve immune function. Additionally, there is evidence that the immune enhancing/anti-inflammatory action can keep increasing for up to 6 months with continued use. (Miller et al. 1999). This means the longer you take SORENZYME™, the better the effects. The data suggests a cumulative effect of the protease enzymes by either the body’s “up-regulating” of its own protection system or by the storage of the supplemented enzymes in muscle tissue until there is a greater need for muscle repair, as with muscle damage and training.

Is SORENZYME™ the same as digestive enzymes?

There is no doubt that once the Labrada team hits the market with the first D.O.M.S. muscle recovery system, the rest of the industry will come out with their imitation formulations. You will also see companies coming out saying digestive enzymes are the same as our muscle recovery enzymes, but that is not the case; let’s clear this issue up! Medical doctors often turn to digestive enzyme products to promote good digestion and enhance nutrient absorption, but not as a means of decreasing inflammation or removal of protein debris that inhibit the return of optimum muscle function.

Our selection and concentration of enzymes are specifically chosen because of their effects on muscle tissue and healing on a systemic (WHOLE BODY) level, not just your digestive system. This means the activity levels of these enzymes are remarkably different from the activity levels of digestive enzymes. So, don’t be fooled! The SORENZYME™ formulation is as unique as it is powerful!