Facts:

• Stubborn fat areas are caused by a high density of Alpah2 receptors.
• Lipolysis must be increased in order for fatty acids (FFAs) to be burned.
• Blood flow to adipose tissue and transportation of FFAs away from adipose tissue is vital to fat loss.
• FFAs must be burned to body fat loss to occur.
• Exercise is the best way to increase blood flow to adipose tissue, transportation of FFAs, and oxidation of FFAs.

Knowing these facts has allowed Scivation to create a thermogenic formula that will assist in burning through fat stores. Scivation has reformulated Dialene 4 to give you more energy and to help you burn more fat through an advanced method never used before—Fat Burning Antioxidants! This new formulation, now called Dialene 4x, targets stubborn fat through many different pathways, ensuring that it is burned! The advanced LipidOx™ blend has been scientifically shown to enhance healthy weight management. You can burn fat and enhance your antioxidant profiles at the same time. Not only does Dialene 4x do this, but it also has other advanced compounds to help enhance energy, mental focus and better yet, fat loss in those stubborn areas like abs for men and hips and thighs for women.

Dialene 4x targets all of the fat loss pathways; Dialene 4x increases lipolysis, Dialene 4x increases blood flow so the fatty acids can be transported to tissues to be burned, Dialene 4x increases the oxidation of fatty acids and blocks the Alpha2 receptors which are responsible for stubborn fat.

210-0032 Scivation Dialene 4X 90 tablets Nutrition Facts Serving Size: 2 Sci-Tabs Servings Per Container: 45 Amount Per Serving % Daily Value* Pyridoxine (B6) (as Pyridoxine HCl) 50  mg 1250%    Cyanocobalamin (B12) (Methylcobalamin) 100  mcg 1667%    Pantothenic Acid (Vitamin B5) 25  mg 250%    G6 Fat Incinerating Matrix (Cayenne Pepper (40,000 HU), USP Caffeine, Hordinine HCl, Synephrine HCl, Vinpocetine, Yohimbine HCl) 665  mg   LipidOX(TM) Blend (PolyphOrac Blend Containing: Astathanthin (1%), FucoXanthin (10%), Grape Skin Extract, Blueberry Extract, Raspberry Powder, Cranberry Powder, Prune Powder, Cherry Powder, Bilberry Extract, Strawberry Powder, Broccoli Cruciferous Extract, Spinach Powder, Tomato Powder, Carrot Powder, Onion Powder) 550  mg   *Percent Daily Values are based on a 2,000 calorie diet.   Other Ingredients: Calcium Phosphate, Stearic Acid, Croscarmelose Sodium, Silicon Dioxide, Magnesium Stearate, FD&C Red #40, Titanium Dioxide, Riboflavin, and Methocellulose. Recommended Use: As a dietary supplement, take two Sci-Tabs 1-2 times daily. Allow 6-8 hours between servings. DO NOT EXCEED MORE THAN 2 SERVINGS IN ANY 24-HOUR PERIOD. Warning: This product contains caffeine. Consult with your physician before using this product, particularly if you are taking prescription medications. Not for persons under the age of 18. Women who are pregnant or nursing should not use this product. Do not use this product if you are at risk for or are being treated for high blood pressure, heart, kidney, thyroid or psychiatric disease, anxiety, depression, seizure disorders or stroke. Before beginning any program of weight loss, consult your health care practitioner. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. If you notice any errors in the information above, please let us know. If you have further questions about this product, please contact Scivation at 1-336-567-0104

Here is the scientific rundown of how Dialene 4x works.

Dialene 4x Targets Norepinephrine and Adrenergic Receptors

Body fat storage is controlled by many different factors ranging from diet to hormones to receptor density. Of importance to this article is receptor density. Without diving to deep into the nerdy, science stuff, a receptor can be looked at like a lock that a key (i.e. a hormone) fits into. The term “adrenaline” is commonly used to refer to the body’s excitatory catecholamines, Epinepherine (E) and Norepinepherine (NE), which are regulators of lipolysis (fat breakdown). NE and E acts on receptors called adrenergic receptors of which there are alpha (1 & 2) and beta (1, 2, & 3) subtypes. Activation of the alpha1 and beta-receptors is lipolytic (causes fat breakdown) while activation of the alpha2 receptor is anti-lipolytic (blunts fat breakdown). Stubborn fat areas have a high density of alpha2 receptors, making it harder for fat breakdown to occur in that area. In order to burn stubborn fat, we must override the inhibitory effect of the alpha2 receptors (which will be discussed later). Now that we know the cause of stubborn fat areas, we need to learn how to burn the fat!

Dialene 4x Targets Stored Triglycerides—Body Fat We Want to Lose

While all cells contain some fat, it is mainly stored in muscle (intramuscular triglycerides) and in adipose tissue (body fat). Adipose tissue is the body’s main fat storage site and the fat we all want to lose. Adipose tissue is divided into individual cells called adipocytes. These adipocytes hold stored triglyceride (1 glycerol molecule bonded to 3 fatty acids) droplets, which serve as a source of energy for the body. These droplets make up 95% of adipocytes’ volume. In order for this storage of potential energy (60,000-100,000 kcal) to be used and to lose bodyfat (everyone’s goal), it must be mobilized through lipolysis (the breakdown of triglycerides). Lipolysis involves splitting the triglycerides into a glycerol molecule and 3 separate fatty acids (FFA). Once the fatty acids diffuse (exit) from the adipocytes, they bind to plasma albumin (a protein in the blood) in order to be transported to active tissues where they can be burned. In order to lose body fat, the fatty acids must be burned!

Dialene 4x Targets aids in the Transport of FFA to be Burned!

Blood flow is of prime importance to the transportation of FFA away from adipocytes and through the circulation to active tissues where they can be burned. This is especially important during exercise where energy requirements are heightened. Low blood flow could cause the accumulation of FFA within adipose tissue resulting in less available FFA to be oxidized and a greater chance of FFA to be turned back into triglycerides. What is the best way to increase blood flow? Exercise! In addition to this certain supplements can also increase blood flow (more on this later). Increasing blood flow throughout the body will assist in losing weight by transporting FFA to where they can be burned.

Dialene 4x increases FFA Oxidation—Burning Body Fat

When the FFAs reach muscle tissue, they are transported into a muscle cell. Once in the muscle cell, the FFAs can re-esterfy (rebind) with glycerol to form triglycerides to be stored in the muscle or bind with intramuscular proteins to be used for energy production in the mitochondria. In the mitochondria, the fatty acids undergo beta-oxidation, meaning they are burned for energy. We want the FFAs to be burned in the mitochondria. Increasing energy demands through exercise is the best way to accomplish but there are supplements that can help give you an extra boost.

B Vitamins: The B vitamins are essential to whole body metabolism, especially fat loss. We included the B vitamins in Dialene 4x to ensure your body has what it needs to burn fat at its full potential. We decided to take out Vitamin B3 (Niacin) from the Dialene 4x formula because some Dialene 4 users did not like the niacin-flush they got from it.

G6 Fat Incinerating Matrix™

Cayenne Pepper: Cayenne peppers have been used for centuries as a folk medicine for stimulating circulation, aiding digestion and relieving pain (topically). Cayenne increases thermogenesis by dilating blood vessels and increasing blood circulation. Blood flow to adipose tissue is very important for the transportation of fatty acids to be burned. Increasing blood flow allows more fatty acids to be delivered to tissues where they can be burned.

Caffeine USP: Caffeine, a plant alkaloid belonging to the drug class methylxanthines and is found in natural sources such as coffee beans, tea leaves, cocoa beans, and other plants, is the world’s most widely used stimulant. Caffeine is a Central Nervous System (CNS) stimulant shown to delay fatigue and improve cognitive performance. Caffeine acts as an adenosine receptor antagonist. Adenosine decreases the release of stimulatory/excitatory neurotransmitters (i.e. norepinephrine [NE]). Therefore, blocking the adenosine receptor allows a greater excitation to occur by increasing NE’s ability to activate the adrenergic receptors. Caffeine inhibits phosphodiesterase (PDE), causing a build-up of cAMP levels and greater effect of NE on fatty acid lipolysis. PDE blunts lipolysis; therefore inhibiting PDE allows lipolysis to proceed at an accelerated rate. The end result is there are more fatty acids available for oxidation after consumption of caffeine. Caffeine addresses the need to increase fat lipolysis so that FFAs can be burned and body fat can be lost.

Hordinine HCL: Hordinine increases the liberation of NE and also decreases its breakdown, leading to both faster and prolonged stimulatory effect from NE. Liberating NE and prolonging its activity will lead to more energy and greater lipolysis. Hordinine also inhibits the Monoamine Oxidases-B (MAO-B) enzyme, which is responsible for the breakdown of dopamine. Dopamine is a catecholamine involved in the regulation of appetite, mood, and other functions. Prolonging dopamine’s activity will lead to an improvement in mood and a decrease in appetite, both of which are beneficial while dieting.

Synephrine HCL: Synephrine is an amine found in the Citrus aurantium fruit. This fruit has been used in Eastern medicine for hundreds of years. Synephrine can increase ones metabolic rate and thermogenesis without any side effects on blood pressure or cardiovascular health. An increased metabolic rate means more calories are burned. Synephrine’s effect on metabolic rate lies in its ability to bind to specific adrenergic receptors, the α-1. This binding effect causes an increase in the body’s ability to metabolize stored body fat as well as a decrease in appetite.

Vinpocetine: Vinpocetine increases circulation and blood flow to the brain. Just like cayenne, vinpocetine’s ability to increase blood flow aids in the transportation of fatty acids to tissues where they can be burned.

Yohimbine HCL: Yohimbine is an alpha2 receptor antagonist. The catecholamine norepinephrine (NE) is released in times of stress and intense activity to increase the amount of available energy by releasing stores nutrients (i.e. fatty acids from fat cells). NE activates both the beta and alpha adrenergic receptors. Activation of the beta receptors increases fatty acid liberation from fat cells while activation of the alpha receptor inhibits liberation of fatty acids. By blocking the alpha2 receptor with Yohimbine, the negative feedback caused by NE binding to the alpha receptors is reduced and fatty acid liberation is increased. Yohimbine has been shown to increase fat loss by increasing the amount of lipid mobilization and oxidation and blood flow to adipose tissue due to alpha2 antagonism. So Yohimbine addresses two of the fat burning principles we are trying to address: alpha2 receptor action and blood flow.

Lipid Ox Blend™

PolyphOrac Blend Containing: Astathanthin (1%), FucoXanthin (10%), Grape Skin Extract, Blueberry Extract, Raspberry Powder, Cranberry Powder, Prune Powder, Cherry Powder, Bilberry Extract, Strawberry Powder, Broccoli Cruciferous Extract, Spinach Powder, Tomato Powder, Carrot Powder, Onion Powder.

We all know that anti-oxidants are vital for overall health and well-being. In addition, recent research has shown anti-oxidants to increase fat loss. Research has shown that anti-oxidants can decrease the production of triglycerides by fat cells. Fat is stored in the form of triglycerides in fat cells. Before stored fat can be burned it must be broken down from the triglyceride form to free fatty acids. Stopping the formation of triglycerides in fat cells will decrease fat storage.

Anti-oxidants are believed to increase fat loss through increased fat utilization during exercise via carnitine palmitoyl transferase (CPT-1) activation and protection. CPT, the rate-limiting enzyme in beta-oxidation of fatty acids in skeletal muscle and liver cell mitochondria, is found on the outer membrane of mitochondria and carries fatty acids across the membrane into the mitochondria by binding to them. Increasing the expression of CPT will allow more fatty acids to be transported into the mitochondria where they can be oxidized.

The LipidOx Blend was designed to contain a high amount of the anti-oxidants research has shown to have a significant effect on fat loss.